Gaines, a 6-foot-6, 334 pounder from White House, signed with the Baltimore Ravens.
Carter, 6-3, 304 pounds, who is from LaVergne, signed with San Francisco.
Gaines and Carter both made the All-OVC First Team last season.
They helped the Tigers average 175.7 yards rushing per game last season, which ranked fourth in the conference.
Reach Mike Organ at 615-259-8021 or firstname.lastname@example.org.